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Predicting Prostate Cancer Recurrence Using a Prognostic Model that Combines Immunohistochemical Staining and Gene Expression Profiling
Predicting Prostate Cancer Recurrence Using a Prognostic Model that Combines Immunohistochemical Staining and Gene Expression Profiling
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机译:结合免疫组织化学染色和基因表达谱分析的预后模型预测前列腺癌的复发
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摘要
An analysis and display system generates and displays a score indicative of whether cancer will recur in a patient. In a learning phase, a phenomic feature of tumor tissue is measured. A corresponding phenomic feature is defined. The phenomic feature may be measured through image analysis of digital images taken of tissue slices stained with IHC-based stains. A genomic feature of the tissue is also measured. This may entail obtaining a probe count indicative of a degree of expression of a particular gene. A bivariate feature is calculated using both the phenomic and genomic information. A network including the bivariate feature is displayed. In a diagnostic phase, raw phenomic and genomic data is obtained from a tissue sample taken from the patient. From the data, a score for the bivariate feature, and scores for the other features, are calculated. The score is a function of the underlying feature scores.
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