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FORMULATIONS OF SITE-SPECIFIC, MICROPARTICULATE COMPOSITIONS AND THEIR USE TO IMPROVE OUTCOME AFTER ANEURSYMAL SUBARACHNOID HEMORRHAGE
FORMULATIONS OF SITE-SPECIFIC, MICROPARTICULATE COMPOSITIONS AND THEIR USE TO IMPROVE OUTCOME AFTER ANEURSYMAL SUBARACHNOID HEMORRHAGE
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机译:特定部位的微微粒组合物的配方及其在非蛛网膜下腔蛛网膜下腔出血后改善结局的用途
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摘要
The described invention provides site-specific sustained release microparticulate formulations containing a therapeutic amount of an L-type voltage gated calcium channel inhibitor, a PLGA polymer comprising from 25% to 50% glycolide, and a hyaluronic acid. A therapeutic amount of the formulation is effective to reduce signs or symptoms of delayed cerebral ischemia comprising one or more of a cortical spreading ischemia, a cortical spreading depolarization, a plurality of microthromboemboli, or an angiographic vasospasm after brain injury in a mammal, while reducing the risk of systemic hypotension, cardiac dysfunction, anoxia, and intracranial hypertension.
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