Methods and Compositions for Treating Cancers by Inhibiting Estrogen Signaling in Myeloid-Derived Suppressor Cells

摘要

Compositions and methods are provided for treating an estrogen receptor negative cancer in a subject with an elevated population of estrogen receptor positive myeloid-derived suppressor cells (MDSCs), including administering a therapeutically effective amount of an estrogen receptor antagonist to the subject in need thereof.