PLASMONIC NANOCAVITY ARRAY SENSORS FOR ANALYTE DETECTION ENHANCEMENT AND METHODS FOR MAKING AND USING OF THE SAME

摘要

This disclosure provides, among other things, a nanosensor for sensing an analyte. In some embodiments the nanosensor comprises (a) a substrate; (b) a signal amplification layer comprising: (i) a substantially continuous metallic backplane on the substrate; (ii) one or a plurality of pillars extending from the metallic backplane or from the substrate through holes in the backplane; and (iii) a metallic disk on top of the pillar, wherein at least one portion of the edge of the disk is separated from the metallic backplane; and (c) a capture agent that specifically binds to the analyte, wherein the capture agent is linked to the surface of the signal amplification layer; wherein the nanosensor amplifies a light signal from an analyte, when the analyte is bound to the capture agent. Methods for fabricating the nanosensor and methods for using the nanosensor are also provided.