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METHOD FOR CONTROLLING CONTINUOUS CHROMATOGRAPHY AND MULTI-COLUMN CHROMATOGRAPHY ARRANGEMENT
METHOD FOR CONTROLLING CONTINUOUS CHROMATOGRAPHY AND MULTI-COLUMN CHROMATOGRAPHY ARRANGEMENT
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机译:连续色谱法和多柱色谱法排列的控制方法
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摘要
Methods of controlling at least one multi-column chromatography arrangement for the continuous process of purifying biopharmaceuticals are provided. The methods include introducing a first multi-component mixture into a column of the multi-column chromatography arrangement; detecting at least one multivariate signal by at least one detector; calculating at least one process parameter on the basis of the multivariate signal by at least one data-processing program of a computing unit via application of a chemometric method; and controlling the purification process via control of at least one controllable control element on the basis of the at least one process parameter.
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