TRYPTOPHANE-2,3-DIOXYGENASE INHIBITOR COMPOUND (TDO) AND / OR INDOLEAMINE-2,3-DIOXYGENASE (IDO), PHARMACEUTICAL COMPOSITION, AND USE OF TRYPTOPHANE-2,3-DIOXYGENASE (TDO) INHIBITOR AND / OR INDOLEAMINE-2,3DIOXYGENASE (IDO) OR PHARMACEUTICALLY ACCEPTABLE SALT OF THE SAME FOR MANUFACTURE OF A MEDICINAL PRODUCT

摘要

A tryptophan-2,3-dioxigenase (tdo) and / or indoleamine-2,3-dioxigenase (acid) inhibitor compound is provided for use in medicine, said compound comprises the following formula: wherein x1, x2, x3, x4 and x 5 may be the same or different and each is independently selected from c, neo; each atom having a dotted line may independently have a double bond or a single bond, provided that the valencies on each atom are maintained; each r1, r2, r3, r4, r5 and r7 may be present or absent and may be the same or different and is selected from h and a substituted or unsubstituted organic group provided that the number of such groups r present is such that the valences of x1, x2, x3, x4 and x5 are maintained; one or two groups r 6 may be present and are selected from h and a substituted or unsubstituted organic group, provided that the number of groups r 6 present is such that the valence of the carbon atom to which they are attached is maintained, and provided that at least one r6 is an organic group comprising an atom double bonded to an oxygen atom (preferably a carbonyl group or a sulfonyl group) at a position a, ß or ¿to the carbon atom to which r6 is attached and to which the double bonded atom is attached. to an oxygen atom is also attached to a heteroatom.