bispecific molecule having one or more epitope binding sites capable of immunospecific binding to (one) pd-1 epitope (s) and one or more epitope binding sites capable of immunospecific binding to (one) epitope (s) -4, and pharmaceutical composition

摘要

The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that have at least one epitope binding site that is immunospecific to a pd-1 epitope and at least one binding to epitope that is immunospecific to an epitope of ctla-4 (i.e., a "pd-1 x ctla-4 bispecific molecule"). the pd-1 x ctla-4 bispecific molecules of the present invention are capable of simultaneous binding to pd-1 and ctla-4, particularly as molecules are arranged on human cell surfaces. The invention is directed to pharmaceutical compositions containing such bispecific pd-1 x ctla-4 molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention relates to methods of using such pd-1 x ctla-4 bispecific molecules to stimulate an immune response.