PROTEIN OF SUPPLY TO BRAIN, METHOD OF TREATMENT AND / OR PROPHYLAXIS OF CEREBRAL DISORDERS IN MAMMALS WHO HAVE OR ARE AT RISK TO DEVELOP THE MADE DISTURBUS AND METHOD OF CERTAIN DIAPHYSIS OF THE CERTAIN DISTRIBUTION FIND AT RISK OF DEVELOPING THE MADE DISTURBANCE

摘要

The present invention relates to a brain delivery protein comprising a target binding antibody that targets the mammalian brain; two carrier moieties, each of which is capable of monovalent interaction with protein expressed on blood-brain barrier endothelial cell (bbb), wherein each of said carrier moieties is linked to a c-terminal end of the target binding antibody.The present invention further relates to the use of such brain supply proteins in therapy or diagnosis or for screening, for example, for neurodegenerative disorders and other brain diseases.