method for inducing stem cell differentiation into hepatocyte, cell composition, method for treating a disorder, disease, or malformation, method for producing differentiated hepatocytes from induced pluripotent stem cells, and method for producing endoderm cells from stem cells induced pluripotent trunk

摘要

a novel method of inducing or producing hepatocytes from human induced pluripotent stem cells in unprecedented efficiency and functionality. The core of the invention is the use of experimentally discovered mRNAs at multiple critical differentiation decision points along pluripotent mesendoderm to hepatocyte endoderm routes in a previously unknown manner.