purified humanized monoclonal antibody, composition and kit for selectively inducing apoptosis in dr-4-expressing target cells, to inhibit proliferation of dr4-expressing target cells, to treat a cancer patient, to treat a patient having an inflammatory or autoimmune disease

摘要

"purified antibody that specifically binds to a dr-4 trail receptor, monoclonal antibody, composition and kit for selectively inducing apoptosis in dr-4-expressing target cells, to inhibit proliferation of dr-4-expressing target cells, to treat a cancer patient, and a patient having an inflammatory or autoimmune disease, isolated nucleic acid, vector, cultured cell, and purified polypeptide. " An antibody of the invention interacts with human dr5 or human dr4 to produce downstream receptor agonistic or antagonistic effects including inhibition of cell proliferation and apoptosis. the nucleic acid sequences and amino acid sequences of the dr5 and dr4 antibodies were elucidated and vectors and cells containing and expressing these sequences were generated. The compositions utilizing the antibodies are detailed including compositions for treating apoptosis-related disease and treating unregulated cell development.