single variable domain of anti-interleukin-1 receptor immunoglobulin type 1, anti-interleukin-1 receptor type 1 antagonist, use thereof, method for oral dispensing or dispensing a drug to a patient's gi tract or lung, or patient lung tissue, pulmonary dispensing device, oral formulation, double specific ligand, isolated or recombinant nucleic acid, vector, host cell, method for producing polypeptide, pharmaceutical composition, polypeptide, fusion protein, and isolated or recombinant nucleic acid .

摘要

single variable domain of anti-interleukin-1 receptor immunoglobulin type 1, anti-interleukin-1 receptor type 1 antagonist, use of same, method for oral or drug-dispensing drug to a patient's gi tract or lung or lung tissue of a patient, pulmonary dispensing device, oral formulation, double specific ligand, isolated or recombinant nucleic acid, vector, host cell, method for producing polypeptide, pharmaceutical composition, polypeptide, fusion protein, and isolated or The recombinant invention relates to anti-yl-1r1 polypeptides and single antibody variable domains (dabs) that are resistant to degradation by a protease, as well as antagonists comprising the same. polypeptides, dabs and antagonists are useful as therapeutic and / or prophylactic products that are likely to find proteases when administered to a patient, for example for a patient's pulmonary administration, oral administration, lung dispensing and gi tract dispensing, as well as for treating inflammatory disease such as arthritis or cup.