PHARMACEUTICAL COMPOSITION FOR CLINICAL AND SUBCLINICAL BOVINE MASTITIS TREATMENT, PREPARATION BASED THEREON, AND TREATMENT METHOD

摘要

The invention relates to veterinary medicine and pharmaceutics, and concerns the development of a broad-spectrum pharmaceutical composition and preparation based thereon for clinical and subclinical bovine mastitis treatment. Proposed is a pharmaceutical composition for bovine mastitis treatment containing nisin in a therapeutically effective amount, polymyxin and excipients, including at least a stabilizer and a preservative, the ratio of nisin and polymyxin being as follows, wt.%: nisin - 90-99, polymyxin - 1-10. Also proposed is a drug product for clinical and subclinical bovine mastitis treatment presented as a liquid selected from an aqueous or oil suspension, or a solution, and containing the foregoing pharmaceutical composition, wherein the concentration of nisin is 0.1-5 wt.%, and the concentration of polymyxin is 0.05-5 wt.%. Also proposed is a method for bovine mastitis treatment that includes daily parenteral administration of the foregoing drug product in the amount of 10 ml per one udder part, in a cycle of 3-7 procedures. The pharmaceutical composition and the preparation based thereon demonstrate high therapeutic efficiency with extended spectrum of action on the bacterial infectious agents, and a low toxicity level.