FICUSNOTINS, RARE DIARYLBULATANOIDS FROM THE LEAVES OF THE PHILIPPINE ENDEMIC PLANT FICUS NOTA (BLANCO) MERR.

摘要

Six rare diarylbutanoids, designated as ficusnotins A-F (1-6), with a rare carbon skeleton consisting of two aromatic rings separated by an unbranched C4-chain have been isolated from the leaves of the Philippine endemic plant Ficus nota. The structures were determined on the basis of spectroscopic data as well as X-ray crystallographic analysis. The isolated compounds were evaluated for their antibacterial activity against Bacillus subtilis. Ficusnotins A-F (1-6) exhibited modest antibacterial activity against B. subtilis with ICso values of 97, 155, 578, 152, 116, and 54 JlM, respectively.