TUMOR VACCINATION INVOLVING A HUMORAL IMMUNE RESPONSE, AND PROTEINS THEREFOR INCLUDING ALL OR A PORTION OF A HEPATITIS B VIRUS CORE ANTIGEN PROTEIN AND AN EPITOPE OF CLAUDIN 18.2

摘要

The present invention relates to tumor immunotherapy, in particular to tumorvaccination, using chimeric proteinscomprising all or a portion of a hepatitis B virus core antigen protein and anamino acid sequence comprising anepitope derived from the extracellular portion of a tumor-associated antigensuch as claudin 18.2. In particular,the present invention provides virus-like particles comprising said chimericproteins, which are useful for elicitinga humoral immune response in a subject against the tumor-associated antigen,in particular against cells carryingsaid tumor-associated antigen on their surface, wherein the tumor-associatedantigen is a self-protein in saidsubject.