PEROXISOME BIOMARKERS IN HIV DISEASE PROGRESSION AND PEROXISOME ACTIVATING DRUGS FOR HIV TREATMENT

摘要

The present disclosure provides methods for assessing likelihood of development of HIV- associated neurocognitive disorder (HAND) in a HIV patient. Also provided herein are methods for treating a HIV patient, such as, a HIV patient with increased level of a mi RNA that downregulates a peroxin and/or decreased level of a peroxisomal activity biomarker and/or increased level of a substrate of a peroxisomal enzyme. The present disclosure also provides methods for monitoring efficacy of a treatment regimen for a HIV patient.