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EVOLUTION OF BIOACTIVE SEQUENCE-DEFINED SYNTHETIC POLYMERS USING DNA-TEMPLATED POLYMERIZATION

机译：DNA模板聚合法对生物活性序列定义的合成聚合物的进化

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摘要

The present invention provides methods and compositions for performing ordered multi- step syntheses involving modified nucleic acids by nucleic acid-mediated chemistry. This approach is useful for generating sequence-defined highly functionalized nucleic acid polymers. The invention also provides modified nucleic acid polymers that bind to proteins of interest (e.g., PCSK9 and IL-6), which are implicated in human disease.

机译：本发明提供了通过核酸介导的化学方法进行涉及修饰的核酸的有序多步合成的方法和组合物。该方法对于产生序列定义的高度官能化的核酸聚合物是有用的。本发明还提供了与感兴趣的蛋白质（例如，PCSK9和IL-6）结合的修饰的核酸聚合物，所述蛋白质与人类疾病有关。 展开▼

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公开/公告号WO2019010441A8

专利类型

公开/公告日2019-01-31

原文格式PDF

申请/专利权人 PRESIDENT AND FELLOWS OF HARVARD COLLEGE;
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申请/专利号WO2018US41127

发明设计人 LIU DAVID R.;CHEN ZHEN;LICHTOR PHILLIP ANDREW;
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申请日2018-07-06

分类号C12N15/10;C12P19/34;C07H21/04;C12N15/67;

国家 WO

入库时间 2022-08-21 11:57:22

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