Biomarker for prenatal diagnosis of twin-to-twin transfusion syndrome

摘要

The twin-to-twin transfusion syndrome (TTTS) is a condition that can occur in 10 to 15% (approximately 150, 000 cases/year worldwide) of monochorionic twin pregnancies. Thus, the present application provides a new molecular based method, which allows early screening of this syndrome in a rapid and non-invasive manner. Using real time quantitative PCR, this method is intended to quantify the expression of