首页> 外国专利> METHODS FOR IDENTIFYING CANCER PATIENTS AT HIGH RISK OF DEVELOPING METASTASIS

METHODS FOR IDENTIFYING CANCER PATIENTS AT HIGH RISK OF DEVELOPING METASTASIS

机译：高发转移风险的癌症患者识别方法

页面导航

摘要
著录项
相似文献

摘要

Methods for identifying cancer patients at high risk of developing metastasis. The present invention relates to the field of biomedicine and cancer. Specifically, it relates to an in vitro method of prognosis or for predicting the risk of suffering from metastasis in a patient having localized cancer disease based on the differential presence of exons in circulating cell free DNA (cfDNA) in cancer patients.

机译：鉴定有高发生转移风险的癌症患者的方法。本发明涉及生物医学和癌症领域。具体而言，本发明涉及一种体外方法，其用于基于局部无循环DNA（cfDNA）中外显子的不同存在来预测患有局部癌症的患者的转移风险。癌症患者。 展开▼

著录项

公开/公告号WO2019068761A1

专利类型

公开/公告日2019-04-11

原文格式PDF

申请/专利权人 INSTITUT DE RECERCA BIOMÈDICA DE LLEIDA FUNDACIÓ DR. PIFARRÉ;FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ;UNIVERSIDAD AUTÓNOMA DE MADRID;CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS;
展开▼

申请/专利号WO2018EP76906

发明设计人 GARCIA OLMO DOLORES C.;OLMEDILLAS LOPEZ SUSANA;GARCIA ARRANZ MARIANO;GARCIA OLMO DAMIÁN;AGUADO OREA BEGOÑA;PEIRO PASTOR RAMÓN;
展开▼

申请日2018-10-03

分类号C12Q1/6886;C12Q1/6809;

国家 WO

入库时间 2022-08-21 11:55:20

相似文献

专利

外文文献

中文文献

1. 一种输电线路通道可视化告警高发线段的识别方法 [P] . 中国专利： CN110502571B . 2020.05.08

2. 输电线路通道可视化告警高发区域的识别方法 [P] . 中国专利： CN110399398B . 2020.04.07

3. ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or at risk of metastasis, to identify a ccr5 antagonist, method for determining whether a human individual having prostate cancer is suffering from or under risk of developing metastasis, to identify a candidate compound, to produce in vitro primary epithelial cells, to diagnose prostate cancer, to select a treatment for an individual having a prostate cancer / tumor, cell line, and, animal model [P] . BR112013023050A8 . 2018-09-25

机译： ccr5拮抗剂，用于确定患有前列腺癌的人是否患有转移瘤或处于转移危险中的方法，以鉴定ccr5拮抗剂，用于确定患有前列腺癌的人的个体患有转移瘤或处于转移危险中的方法，以鉴定一种候选化合物，用于产生体外原代上皮细胞，诊断前列腺癌，为患有前列腺癌/肿瘤，细胞系和动物模型的个体选择治疗方法

4. methods for screening for a therapeutic agent, for suppressing the polynucleotide sequence, for treating a non-steroidal cancer, for screening for binding of an agent specifically to a polynucleotide, and for determining whether a patient is at risk for developing or having a non-steroidal cancer, pharmaceutical composition, uses of a therapeutic agent, an antisense molecule or a cell that expresses and / or contains the antisense molecule, at least one of the immunogenic membrane proteins, fragments, derivatives or homologues thereof or from a cell containing and / or expressing at least one of the immunogenic membrane proteins or fragments, derivatives or homologues thereof and an agent or antibody, agent, and kit for identifying a patient at risk of developing or have non-steroidal cancer [P] . BRPI0414446A . 2006-11-14

机译：筛选治疗剂，抑制多核苷酸序列，治疗非甾体类癌症，筛选试剂特异性结合多核苷酸的方法以及确定患者是否处于发展或患有非糖尿病风险的方法类固醇癌，药物组合物，表达和/或含有反义分子的治疗剂，反义分子或细胞，免疫原性膜蛋白，其片段，衍生物或同源物中至少一种或来自含有和/或含有细胞的细胞的用途或表达至少一种免疫原性膜蛋白或其片段，衍生物或同系物以及一种试剂或抗体，试剂和试剂盒，用于鉴定有发生或患有非甾体癌风险的患者

5. methods of identifying a genetic variant that is associated with the development of a condition of interest and a patient in a clinical trial of a treatment for alzheimer's disease, of determining increasing risks of developing a condition of interest, alzheimer's disease in a patient , a prognosis, or the risk of developing alzheimer's disease in a patient, treating a patient for alzheimer's disease, a condition of interest and alzheimer's disease in a patient, stratifying a patient into a subgroup of a clinical trial of a therapy for the treatment of alzheimer's disease, use of an active anti-alzheimer's disease agent, and kits to determine if a patient is at increased risk of developing alzheimer's disease and if a patient is responsive to treatment for a condition of interest [P] . BRPI0917948A2 . 2017-06-20

机译：在阿尔茨海默氏病治疗的临床试验中鉴定与目标疾病和患者发展相关的遗传变异的方法，确定在患者中发展目标疾病阿尔茨海默氏病的风险，以及预后，或在患者中罹患阿尔茨海默氏病的风险，在患者中治疗阿尔茨海默氏病，所关注的疾病和阿尔茨海默氏病的风险，将患者分为治疗阿尔茨海默氏病的临床试验的亚组，活性抗阿尔茨海默氏病药物的使用和试剂盒，以确定患者是否罹患阿尔茨海默氏病的风险增加，以及患者是否对所关注疾病的治疗有反应

1. Radiomics-based predictive risk score: A scoring system for preoperatively predicting risk of lymph node metastasis in patients with resectable non-small cell lung cancer [J] . Lan He, Yanqi Huang, Lixu Yan, 中国癌症研究（英文版） . 2019,第004期

2. Validation of nutritional risk index method against patient-generated subjective global assessment in screening malnutrition in colorectal cancer patients [J] . Elnaz Faramarzi, Reza Mahdavi, Mohammad Mohammad-Zadeh, 中国癌症研究（英文版） . 2013,第005期

3. Identifying Clinicopathological Risk Factors of the Regional Lymph Node Metastasis in Patients with T 1-2 Mucinous Breast Cancer: A Population-Based Study [J] . Yu Min, Xiaoyuan Wei, Hang Chen, Journal of oncology . 2021,第a期

4. Integrative 3 ' Untranslated Region-Based Model to Identify Patients with Low Risk of Axillary Lymph Node Metastasis in Operable Triple-Negative Breast Cancer [J] . Wang Lei, Hu Xin, Wang Peng, The oncologist . 2019,第1期

5. Expression of fascin-1 and MAP17 in breast cancer identifies high risk patients prone to disease recurrence and/or metastasis [J] . Tampakis A., Tampaki E. C., Nonni A., The Breast : . 2019,第Suppla1期

6. Developing a Low Cost Image Marker to Identify Lymph Node Metastasis for Cervical Cancer Patients: An Initial Study [C] . Wei Liu, Shiyu Pei, Xuxin Chen, Conference on Biophotonics and Immune Responses . 2020

7. Patient satisfaction among lesbians and bisexual and heterosexual women and their risks for developing breast and cervical cancer. [D] . Nelson, Karen Ann. 2003

8. Reverse-Phase Protein Array for Prediction of Patients at Low Risk of Developing Bone Metastasis From Breast Cancer [O] . Naoki Hayashi, Ganiraju C. Manyam, Ana M. Gonzalez-Angulo, 2014

9. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

10. The Feasibility of Using a Population-Based Tumor Registry to Identify Occupational/Industrial Cohorts at Elevated Risks of Developing Cancer [R] . Lassiter, D. V. , Schulman, J. , Siqueira, S. L. , 1980

1. Risk factors for intraocular metastasis of primary liver cancer in diabetic patients:Alpha-fetoprotein and cancer antigen 125 [J] . Kang Yu ,Jing Tang ,Jie-Li Wu . 世界糖尿病杂志：英文版（电子版） . 2021,第2期

2. Identifying high-risk individuals for gastric cancer surveillance from western and eastern perspectives: Lessons to learn and possibility to develop an integrated approach for daily practice [J] . Duc Trong Quach ,Toru Hiyama ,Takuji Gotoda . 世界胃肠病学杂志：英文版 . 2019,第27期

3. Applying Multinational Association of Supportive Care of Cancer Index Score for Identifying Febrile Neutropenia Patients at High Risk of Complications at Tertiary Care Hospital, Pakistan [J] . Zarka Samoon ,Madiha Beg ,Munira Shabbir Moosajee . 流行病学期刊（英文） . 2017,第2期

4. 临终关怀中晚期癌症患者及晚期非癌症患者生存质量调查研究 [C] . 薛莲 ,杨继群 ,马克 . 临终关怀（舒缓疗护）伦理与实践国际研讨会 . 2014

5. 小组工作介入癌症患者照顾者焦虑情绪舒缓的实务研究--以G省Z医院癌症患者照顾者为例 [A] . 肖洁 . 2020