FUSION PROTEIN FOR BLOCKING PD-1/PD-L1 SIGNALING PATHWAY AND ACTIVATING T CELLS AND USE THEREOF

摘要

The present invention provides a fusion protein for blocking PD-1/PD-L1 signaling pathway and activating T cells, comprising (i) an antigen-binding fragment derived from an anti-PD-1 antibody and/or an anti-PD-L1 antibody; (ii) a Fc domain of an immunoglobulin; and (iii) CD80 extracellular domain (ECD). The present invention also provides a polynucleotide encoding the fusion protein, a vector comprising the polynucleotide, a host cell comprising the polynucleotide or vector, and a use of the fusion protein in treating, preventing, and/or diagnosing a disease related to activated PD-1/PD-L1 signaling pathway and inhibited T cell function in an individual.