SOLID FORMS OF TENAPANOR AND METHOD OF PREPARATION OF TENAPANOR

摘要

The invention relates to solid forms of tenapanor, in particular to crystalline form I of tenapanor free base and to solid tenapanor salts, and to methods of preparation thereof. The crystalline form I is the first known crystalline form of tenapanor. The novel solid forms of tenapanor can be used for purification of tenapanor and/or in pharmaceutical compositions. Furthermore, the invention provides a method of preparation of crystalline tenapanor which is economically effective and capable of being scaled up.