TGF-ß RECEPTOR FUSION PROTEINS AND OTHER TGF-ß ANTAGONISTS FOR REDUCING TGF-ß SIGNALING

摘要

The present invention provides TGF-β antagonists and conjugates thereof, as well as methods of using such compositions for attenuating TGF-β signaling. These novel compositions and methods may be useful for treating individuals suffering from devastating diseases associated with elevated TGF-β signaling, including skeletal disorders, such as osteogenesis imperfecta (OI), and muscular diseases, such as muscular dystrophies.