ANTIBODY FOR DETECTING EARLY DAMAGE TO BLOOD-BRAIN BARRIER IN ISCHEMIC STROKE AND USE THEREOF

摘要

The present invention relates to the field of disease detection. Specifically disclosed are a specific antibody used for detecting early damage to the blood-brain barrier in ischemic stroke and the use thereof. The antibody is characterized in that same only specifically recognizes SKLSHIKKMVGDYDR in a degraded fragment of an occludin protein rather than recognizes the full-length protein of the occludin. Therefore, the antibody can be used for specifically detecting the early damage to the blood-brain barrier in ischemic stroke, can exclude the impact of the full-length protein of the occludin in serum on detection results, and can significantly improve the specificity and accuracy for the detection of the early damage to the blood-brain barrier in ischemic stroke.