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PHARMACEUTICAL COMBINATION COMPRISING EXTENDED-RELEASE TRAMADOL HYDROCHLORIDE AND IMMEDIATE-RELEASE ETORICOXIB, AND ITS USE FOR THE TREATMENT OF PAIN
PHARMACEUTICAL COMBINATION COMPRISING EXTENDED-RELEASE TRAMADOL HYDROCHLORIDE AND IMMEDIATE-RELEASE ETORICOXIB, AND ITS USE FOR THE TREATMENT OF PAIN
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机译:缓释盐酸曲马多和速释依托昔布的药物组合及其在疼痛治疗中的应用
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摘要
A pharmaceutical combination comprising: i) a first formulation of extended- release tramadol hydrochloride containing from 2.0% to 12.0% w/w of tramadol hydrochloride, and ii) a second formulation of immediate-release etoricoxib containing from 6.0% to 18% w/w of etoricoxib, solvents or carrier; manufacturing process to prepare the pharmaceutical combination and the individual formulations, wherein the combination is presented in a single dosage form such as, capsules, tablets, bilayer tablets, granulates and sachets. The present invention provides methods of preventing and treating pain, such as acute pain, and the use of the pharmaceutical combination for the prevention and treatment of pain, such as acute pain.
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