Disclosed are a NF-κB-initiating tumor cell specific-effect gene expression vector and an expression product and an application thereof. The gene expression vector contains two sequence elements, i.e., a promoter sequence for regulating gene expression and an effect gene coding sequence at the downstream of the promoter sequence. The promoter sequence is formed by an NF-κB response sequence and a minimum promoter sequence. When the gene expression vector is imported into a tumor cell, a sequence-specific transcription factor NF-κB in the cell can activate the vector to express an effect gene on the vector. The effect gene expression product is a polypeptide or protein of on the cell surface. The polypeptide or protein on the cell surface not only can be used as a new antigen substance for exciting an in-vivo immune system to attack the cancer cell and developing the efficacy of tumor immunity treatment, but also can be used as a cancer cell artificial marker for tumor imaging, diagnosis, cell separation and the like.
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