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PROTECTIVE INTERFERING NUCLEIC ACID MOLECULE AND VIRUS-LIKE PARTICLE, VIRAL VECTOR, OR VIRUS PARTICLE CONTAINING THE SAME AS WELL AS PHARMACEUTICAL COMPOSITION CONTAINING THE PROTECTIVE INTERFERING NUCLEIC ACID AND ITS USE
PROTECTIVE INTERFERING NUCLEIC ACID MOLECULE AND VIRUS-LIKE PARTICLE, VIRAL VECTOR, OR VIRUS PARTICLE CONTAINING THE SAME AS WELL AS PHARMACEUTICAL COMPOSITION CONTAINING THE PROTECTIVE INTERFERING NUCLEIC ACID AND ITS USE
In a first aspect, the present invention relates to an isolated nucleic acid molecule, in particular, an RNA molecule containing particular substitutions. In a further aspect, the present invention relates to a composition comprising the same as well as virus-like particle, viral vector or virus particle containing the nucleic acid molecule according to the present invention. The virus-like particle, the viral vector or the virus particle is suitable for use as a medicament in particular for treating viral infection. Further, a pharmaceutical composition is provided in particular suitable for use as a pharmaceutical prophylactic vaccine containing the virus-like particle, viral vector or the virus particle or the nucleic acid molecule according to the present invention. Finally, a vaccine for vaccination against viral infection, in particular, influenza viral infection is provided as well as a composition or kit comprising the virus-like particle, viral vector or the virus particle according to the present invention or the nucleic acid molecule according to the present invention in a combination with a wild type viral vector or wild type virus particle said composition or kit is suitable for use in treating or protecting against viral infection.
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