S6K2 BLOCKADE PERTURBS REDOX BALANCE AND FATTY ACID METABOLISM, LEADING TO OXIDATIVE CELL DEATH IN MAPK INHIBITOR RESISTANT CANCERS

摘要

NRAS Mutant melanoma cells involve certain pathways for induction of ferroptosis. Accordingly, our studies indicate that cancers with MAPK inhibitors will also be susceptible to treatment with the ferroptosis inducing agents. In a particular example, RAS mutant cancers, such as pancreas, lung, colon and thyroid, as non-limiting examples, would be susceptible to treatment with a ferroptosis/lipid peroxidation inducing agent as provided for in the examples, data, and methods as described herein.