10BPinacolborane 10B-L-4-boronophenylalanine LBPA New synthetic method for 10B-L-4-boronophenylalanine LBPA using 10Bpinacolborane

摘要

The present invention relates to a method for synthesizing [ ¹⁰ B] LBPA, which is a boron compound used in a new chemotherapy treatment technique, boron neutron capture therapy (BNCT). More specifically, the present invention relates to important intermediates of [B ^10] Synthesis and method Synthesis of [B ^10] LBPA using the same for the synthesis of pinacolborane. According to the present invention, [ ¹⁰ B] LBPA used in clinical tests of BNCT, which is a new chemotherapeutic technique with minimal side effects on normal cells, can be mass-produced with high 10B efficiency and easy synthesis method.