- Superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid for MRI and magnetic hyperthermia

摘要

The present invention relates to a superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid for magnetic resonance imaging and magnetic hyperthermia. According to the present invention, a superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid having target specificity and including high-density ultrafine gold nanoparticles uniformly coupled to the surface of protein nanoparticles can be manufactured without a separate surface stabilization process or a target specificity giving process. Accordingly, the superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid exhibits excellent biocompatibility and has excellent target specificity in comparison to existing gold nanoparticles, and a temperature increasing capability and functionality as a T2-MRI contrast medium in an alternating current magnetic field by superparamagnetic properties of the ultrafine gold nanoparticles were verified. Therefore, the superparamagnetic gold nanoparticle cluster-protein nanoparticle hybrid can be used as a key technology in magnetic hyperthermia and magnetic resonance imaging fields.