aMTD aMTD aMTD ADVANCED MACROMOLECULE TRANSDUCTION DOMAIN AMTD SEQUENCES FOR IMPROVEMENT OF CELL-PERMEABILITY POLYNUCLEOTIDES ENCODING THE SAME METHOD TO IDENTIFY THE UNIQUE FEATURES OF AMTDS COMPRISING THE SAME METHOD TO DEVELOP THE AMTD SEQUENCES COMPRISING THE SAME

摘要

The present invention relates to a method for the production of a macromolecular cell for transferring a biologically active macromolecule into a cell, particularly by developing a high-quality macromolecular transfer domain (aMTD) which is an improved hydrophobic cell permeable peptide (CPP) that effectively transfers a biologically active molecule into a plasma membrane. (MITT), a polynucleotide encoding the same, a method for identifying the same, a system for genetically manipulating a biologically active substance having a highly improved cell permeability using the same, and a method for introducing a biologically active molecule into a cell , And uses thereof.