-CD73 ANTI-CD73 ANTIBODIES AND USES THEREOF

摘要

An anti-CD73 antibody or fragment thereof is provided. Thus, the antibody or fragment comprises a VH CDR1 of SEQ ID NO: 1, a VH CDR2 of SEQ ID NO: 2, a VH CDR3 of SEQ ID NO: 3, a VL CDR1 of SEQ ID NO: 4, a VL CDR2 of SEQ ID NO: 5, and SEQ ID NO: 6 VL CDR3, or these variants. More generally, antibodies or fragments thereof are described that have specificity for one or more amino acid residues selected from the C-terminal half of a human CD73 protein, such as the C-terminal domain. Specific epitope amino acids in these domains include Y345, D399, E400, R401 and R480. Also provided are methods of using the antibody or fragment thereof to treat and diagnose a disease such as cancer.