8S9R-5--8-4--9-1--1H-124--5--89--2H-432-DE-37H- CRYSTALLINE 8S9R-5-FLUORO-8-4-FLUOROPHENYL-9-1-METHYL-1H-124-TRIAZOL-5-YL-89-DIHYDRO-2H-PYRIDO432-DEPHTHALAZIN-37H-ONE TOSYLATE SALT

摘要

The invention, including the crystalline form, (8 S, 9 R) -5- fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazole 5-yl) 8,9-dihydro -2 H - pyrido [4,3,2- de] phthalazine -3 (7 H) - the on-tosylate salt form, and provides a method of manufacturing do. Further, (8 S, 9 R) -5-fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazol-5-yl) -8 , 9-dihydro -2 H - pyrido [4,3,2- de] phthalazine -3 (7 H) - and a pharmaceutical composition comprising an on-tosylate salt, treating a disease or condition, such as cancer, to (8 S, 9 R) -5-fluoro-8- (4-fluorophenyl) -9- (1-methyl -1 H -1,2,4- triazol-5-yl) -8, 9-dihydro -2 H - provides a method of using the on-tosylate salt-pyrido [4,3,2- de] phthalazine -3 (7 H).