/ Nanoparticulate phosphate adsorbent on the basis of maghemite or maghemite/magnetite production and uses thereof

摘要

The present invention relates to an iron oxide core comprising (i) an iron oxide core comprising a crystal structure of inverse spinel iron oxide, (ii) a monomeric carbohydrate (particularly a monosaccharide or a disaccharide), alditol, (Iii) a pharmaceutical excipient based on maghemite or maghemite / magnetite, comprising a pharmaceutical excipient selected from a carbohydrate polymer, and / or (iii) a pharmaceutical excipient selected from carbohydrate polymers. As such, the phosphate adsorbent of the present invention has the form of nanoparticles having an iron oxide core particle size of less than 20 nm. The present invention also relates to a method for producing a phosphate adsorbent based on maghemite or maghemite / magnetite; A pharmaceutical composition comprising the phosphate adsorbent; And to the medical use of such phosphate adsorbents, in particular to the prevention and / or treatment of hyperphosphatemia.