pH --- Nanogel using pH sensitive block copolymer polyaspartic acid-graft-imidazole-polyethylene glycol and preparing method thereof

摘要

The present invention relates to a nano-gel using a pH-sensitive block copolymer, poly (aspartic acid-graft-imidazole) -polyethylene glycol, and a process for preparing the same. The present invention relates to a poly (aspartic acid-graft-imidazole) PH-sensitive nanogels were prepared through chemical cross-linking between polyethylene glycol and chemically modified bis-N-hydroxysuccinimide (bis-NHS) conjugated polyethylene glycols, (PH between 7.2 and pH 6.5) due to their chemical nature (appropriate pK _a value, wide buffer pH range, nano size, positive zeta potential and morphology) and pH dependent properties Interaction can regulate drug release and increase drug efficacy on target cells through reversible swelling and endosomal destruction. Therefore, a nanogel using poly (aspartic acid-graft-imidazole) -polyethylene glycol having the above effect can be utilized as a drug delivery composition for tumor treatment.