MAGNESIUM COMPOSITIONS FOR MODULATING THE PHARMACOKINETICS AND PHARMACODYNAMICS OF INSULIN AND INSULIN ANALOGS AND INJECTION SITE PAIN

摘要

Compositions and methods that regulate the pain of the injection site associated with fast-acting injectable insulin formulations have been developed for subcutaneous injection. The formulations may be formulated with zinc chelates such as ethylenediamine tetraacetic acid (" EDTA "), dissolution / stabilizing agents such as citric acid and / or sodium citrate, one or more magnesium compounds and optionally insulin . The new proposals include a method for enhancing absorption by mixing in a container containing an immediate-type enriched insulin formulation and a dry powder excipient to enhance the absorption of commercially available rapid-acting analogous formulations. Also described are devices that mix together the excipient and insulin and minimize the residence time of the mixture.