Composite hydrogel for cell encapsulation comprising collagen and silk fibroin and manufacturing method thereof

摘要

The present invention provides a method for preparing a composite hydrogel for cell encapsulation comprising collagen and silk fibroin, comprising mixing and gelling a collagen having an α-helical structure and a silk fibroin having a β-sheet structure, and prepared accordingly. It relates to a complex hydrogel for cell encapsulation. The composite hydrogel of the present invention exhibits rigidity of 0.05 kPa to 40 kPa suitable for most tissues, enables cell encapsulation, helps cell adhesion and proliferation, inhibits contraction by cell traction, in vitro culture and in vivo Can have long-term beneficial effects on tissue engineering.