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OBTAINING GENERALLY-ENGINEERING T-CELLS BY TRANSPOSONE 'SLEEPING BEAUTY' IN COMBINATION WITH THE SELECTION OF METOTREXATOM
OBTAINING GENERALLY-ENGINEERING T-CELLS BY TRANSPOSONE 'SLEEPING BEAUTY' IN COMBINATION WITH THE SELECTION OF METOTREXATOM
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机译:转座子“睡美人”结合选择甲氨蝶呤获得全身工程化的T细胞
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摘要
The present invention provides nucleic acids, vectors, host cells, methods and compositions to confer and/or augment immune responses mediated by cellular immunotherapy, such as by adoptively transferring CD8+ central memory T cells or combinations of central memory T cells with CD4+ T cells that are genetically modified to express a chimeric receptor. In some alternatives the genetically modified host cell comprises a nucleic acid comprising a polynucleotide coding for a ligand binding domain, a poly nucleotide comprising a customized spacer region, a polynucleotide comprising a transmembrane domain, and a polynucleotide comprising an intracellular signaling domain. In some alternatives, the ligand binding domains binds to CD171.
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