STRAIN OF INFLUENZA VIRUS B/NOVOSIBIRSK/40/2017-MA FOR STUDYING THERAPEUTIC AND PREVENTIVE EFFICACY OF ANTIVIRAL PREPARATIONS IN VITRO AND IN VIVO

摘要

FIELD: biotechnology.;SUBSTANCE: invention relates to biotechnology, medical virology and can be used in investigating the effectiveness of therapeutic and preventive preparations for influenza B virus. Strain of influenza virus B/Novosibirsk/40/2017-MA is intended for studying therapeutic and preventive efficacy of antiviral preparations in vitro and in vivo. Strain is produced on the basis of the original passportized antigenic parent strain of influenza virus B/Novosibirsk/40/2017 by blind passaging through the mice lungs and passage in the MDCK cell culture. Strain is deposited in the Collection of cultures of microorganisms of the State Research Center of Virology and Biotechnology "Vector" under registration number V-811.;EFFECT: strain is adapted to mice and is able to induce non-lethal influenza infection in mice, which enables to investigate therapeutic and preventive efficacy of antiviral preparations in vivo, as well as in vitro on MDCK cell culture.;1 cl, 4 dwg, 2 tbl, 4 ex