SHAR-PEI AUTO INFLAMMATORY DISEASE IN SHAR-PEI DOGS

摘要

In a first aspect, the present invention relates to a method for analyzing a Shar-Pei dog for a genetic predisposition to develop Shar-Pei auto inflammatory disease (SPAID) or for identifying dogs suffering from SPAID. More specifically, the present invention relates to identifying the missense mutation MTBP:g.19383758GA as a marker for genetic predisposition to develop SPAID or for identifying dogs suffering from SPAID. Further, the present invention relates to the use of said mutation for determining the genetic predisposition or for determining SPAID in said dog as well as to isolate nucleic acid sequences and probes useful in these methods. In addition, a kit or test system is provided for analyzing a genetic predisposition of a Shar-Pei dog to develop SPAID or for identifying dogs suffering from SPAID based on mutations in the MTBP gene, in particular, determining the mutation of MTBP:g.19383758GA.