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HETEROTOPIC OSSIFICATION AND METHOD OF TREATMENT
HETEROTOPIC OSSIFICATION AND METHOD OF TREATMENT
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机译:异视骨化症和治疗方法
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摘要
The present inventors have uncovered the nature of heterotopic ossification HO progression as an excessive activation of TGF-β in recruitment of MSCs for osteogenesis in coupling with type H vessel formation. Systemic injection of TGF-β neutralizing antibody using the methods of the present invention, effectively attenuated HO progression in multiple different HO animal models. The present invention provides methods for prophylaxis and treatment of HO and also rare genetic diseases such as fibrodysplasia ossificans progressive (FOP) (also known as myositis ossificans progressive) and progressive osseous heteroplasia (POH).by inhibition of TGF-β.
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