The present invention provides a composition for use in prophylactic treatment or therapeutic treatment of giant cell tumor occurring in a bone and soft tissue or chondrosarcoma, which comprises zaltoprofen. The composition for use in prophylactic treatment or therapeutic treatment of the present invention comprises a radical therapeutic agent or radical therapeutic material that can cause apoptosis in giant cell tumor occurring in a bone and soft tissue or chondrosarcoma to make the tumor disappear, and can induce differentiation of the tumor into fat cells to make the tumor disappear.
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