首页>
外国专利>
GENETICALLY MODIFIED IMMUNE EFFECTOR CELLS AND GENETICALLY ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
GENETICALLY MODIFIED IMMUNE EFFECTOR CELLS AND GENETICALLY ENGINEERED CELLS FOR EXPANSION OF IMMUNE EFFECTOR CELLS
展开▼
机译:遗传修饰的免疫效应细胞和遗传工程化细胞用于扩增免疫效应细胞
展开▼
页面导航
摘要
著录项
相似文献
摘要
To provide improved T-cells and CAR constructs that allow for control of in vivo persistence.SOLUTION: The present invention provides a genetically engineered antigen presenting cell (APC) comprising a transgene encoding a target antigen and a transgene encoding human leukocyte antigen (HLA). In some aspects, the genetically engineered APC may additionally include one or more transgenes encoding a costimulator (e.g., IL-15). Such genetically engineered APCs may be used, for example, in methods for expansion of T cells (e.g., CAR T cells) ex vivo, or may be administered to a control in order to stimulate the growth of antigen-specific T cells in vivo. Thus, the cells provided herein may be used to stimulate the growth of antigen-specific T cells to treat a disease (e.g., cancer).SELECTED DRAWING: None
展开▼