Novel anti-uromodulin antibody, method and assay kit for measuring blood uromodulin concentration using the antibody, and method for evaluating renal function using the kit

摘要

PROBLEM TO BE SOLVED: To provide a method for measuring uromodulin concentration in ground blood, a method for evaluating renal function using the measurement of uromodulin concentration in blood, detection of early renal hypofunction, and a method for evaluating renal reserve/renal vulnerability. To do. A monoclonal antibody against uromodulin having the amino acid sequence set forth in SEQ ID NO: 1 of the Sequence Listing is provided. The monoclonal antibody comprises the amino acid sequence shown in SEQ ID NO: 2 or 3 of the sequence listing, and the amino acid sequences translated from the 163-201, 262-321 and 322-381 of the human uromodulin nucleotide sequence. Provided are a monoclonal antibody having any one selected from the group consisting of antigen epitopes, and a highly sensitive assay kit for uromodulin using two of them. [Selection diagram]