Evaluation system of water permeability of lipid bilayer membrane, evaluation method of water permeability of lipid bilayer membrane, and screening method of drug controlling water permeability of lipid bilayer membrane

摘要

PROBLEM TO BE SOLVED: To easily and accurately evaluate the water permeability of a lipid bilayer membrane and the water permeability of a water channel embedded in the lipid bilayer membrane, and clarify the control mechanism of the water channel and the drug action on the water channel. Systems and methods for implementing A lipid bilayer membrane water permeability evaluation system according to the present invention internally comprises a first aqueous solution, a lipid bilayer membrane, and a second aqueous solution having a higher osmotic concentration than the first aqueous solution. A tube (5) in which an aqueous solution is arranged in this order and which is provided with an opening/closing part (15), a movement distance meter (50) for measuring the movement distance of a lipid bilayer membrane, and a lipid bilayer An electrode pair (40, 41) for measuring/controlling and/or measuring a potential difference and a current across the membrane is provided. [Selection diagram] Figure 1