Method to detect single cell characterization based therapy of circulating tumor cells (CTCs) in metastatic disease

摘要

The present disclosure provides a method of identifying a cell type associated with a response to abiraterone or enzalutamide in a cancer patient, or the presence or absence of a cell type, comprising: (a) Performing a direct analysis including immunofluorescent staining and morphological characterization to identify and enumerate circulating tumor cells (CTCs); (b) isolate the CTCs from the sample; ) Individually characterizing the parameters to produce a profile for each of the CTCs; and (d) identifying biomarker CTCs, wherein the presence or absence of the biomarker is Provided is the above method, which shows a response to abiraterone or enzalutamide in a cancer patient. [Selection diagram] Figure 1A