Tumor antigen-specific T cells against HTLV-1 virus infection including adult T-cell leukemia

摘要

PROBLEM TO BE SOLVED: To provide novel agents for treating adult T cell leukemia/lymphoma.SOLUTION: The invention provides a therapeutic pharmaceutical composition for treating diseases caused by human T cell leukemia virus type I (HTLV-I), which comprises a recombinant lymphocyte expressing a recombinant T cell receptor (TCR), where the lymphocyte is CD8cytotoxic T lymphocyte (CTL), the recombinant T cell receptor (TCR) is HLA-A24-restricted with a specificity to Tax301-309 of Tax protein encoded by HTLV-I and comprises a β chain protein containing a complementarity determining region 3 (CDR3) comprising an amino acid sequence selected from the group consisting of SEQ ID NOs: 1-28, where the composition is used in T cell transfusion therapy.SELECTED DRAWING: None