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Curcumin derivative, its production method, and a photoacoustic imaging agent for detecting beta-amyloid plaque containing it.
Curcumin derivative, its production method, and a photoacoustic imaging agent for detecting beta-amyloid plaque containing it.
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机译:姜黄素衍生物,其制备方法和用于检测包含它的β-淀粉样蛋白斑的光声成像剂。
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摘要
The present invention relates to a curcumin derivative, a method for producing same, and a photo-acoustic imaging agent comprising the curcumin derivative for detecting beta-amyloid plaque. The curcumin derivative, expressed by chemical formula 1, according to the present invention exhibits superb selective bonding with beta-amyloid, thereby allowing beta-amyloid to be detected by means of an optical or photo-acoustic imaging methods, and, particularly, the curcumin derivative can highly effectively detect photo-acoustic signals with almost no noise by reacting to irradiation of light having a particular wavelength range, and thus can be useful as a composition for detecting beta-amyloid and for diagnosing diseases caused by excessive production of beta-amyloid.
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