Transgenic silkworm and method for producing unnatural amino acid-containing protein using the silkworm

摘要

A DNA comprising a sequence containing any one of the following amino acid sequences (a) to (c), and encoding a protein having an activity of binding a desired unnatural amino acid to a phenylalanine-specific tRNA; and Transgenic silkworm, which has a promoter that causes silk gland-specific expression. (A) an amino acid sequence having a mutation at amino acid number 432 of the amino acid sequence shown in SEQ ID NO: 1; (b) one or several amino acids are deleted or inserted at a site other than amino acid number 432 in (a). (C) an amino acid sequence having 80% or more identity at a site other than amino acid number 432 in (a)