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Vaccines against carbapenem-resistant Klebsiella pneumoniae

机译：耐碳青霉烯类肺炎克雷伯菌的疫苗

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摘要

The present invention relates to synthetic saccharides of general formula (I): V*—[U_x+2—U_x+1—U_x]_n—V—O-L-NH₂that are related to carbapenem-resistant Klebsiella pneumoniae capsular polysaccharide and conjugates thereof. Said conjugates and pharmaceutical composition containing said conjugates are useful for prevention and/or treatment of diseases associated with carbapenem-resistant Klebsiella pneumoniae. Furthermore, the synthetic saccharides of general formula (I): V*—[U_x+2—U_x+1—U_x]_n—V—O-L-NH₂are useful as marker in immunological assays for detection of antibodies against carbapenem-resistant Klebsiella pneumoniae bacteria. 展开▼

机译：本发明涉及通式（I）的合成糖：V *-[U _{x + 2 -U _{x + 1 -U _{x ] _{n -V-OL-NH _{2 与耐碳青霉菌的肺炎克雷伯菌荚膜多糖及其缀合物有关。所述结合物和含有所述结合物的药物组合物可用于预防和/或治疗与耐碳青霉烯类的肺炎克雷伯氏菌相关的疾病。此外，通式（I）的合成糖：V *-[U _{x + 2 -U _{x + 1 -U _{x ] _{n -V-OL-NH _{2 在免疫测定中可作为标记，用于检测抗碳青霉烯类肺炎克雷伯菌细菌的抗体。}}}}}}}}}} 展开▼

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公开/公告号US10688169B2

专利类型

公开/公告日2020-06-23

原文格式PDF

申请/专利权人 MAX-PLANCK-GESELLSCHAFT ZUR FÖRDERUNG DER WISSENSCHAFTEN E.V.;
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申请/专利号US201615560719

发明设计人 PETER H. SEEBERGER;CLANEY LEBEV PEREIRA;GUOZHI XIAO;NAEEM KHAN;CHAKKUMKAL ANISH;
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申请日2016-03-29

分类号C07H15/04;C07H15/08;A61K31/702;A61K31/7028;A61K39/108;A61K39;

国家 US

入库时间 2022-08-21 11:31:26

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