首页> 外国专利> Methods for affecting Salmonella infections

Methods for affecting Salmonella infections

机译：影响沙门氏菌感染的方法

展开▼

页面导航

摘要

著录项

相似文献

摘要

The invention relates to methods promoting the aggregation of Salmonella bacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection. 展开▼

机译：本发明涉及促进沙门氏菌在受试者肠道中聚集，从而提供免疫排斥和限制细菌进入，从而减少粘膜和全身感染的方法。展开▼

著录项

公开/公告号US10829542B2

专利类型

公开/公告日2020-11-10

原文格式PDF

申请/专利权人 CSL BEHRING AG;CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS;
展开▼

申请/专利号US201716470663

发明设计人 BLAISE CORTHÉSY;GILLES BIOLEY;CÉDRIC PIERRE VONARBURG;
展开▼

申请日2017-12-20

分类号A61K39;A61K39/02;A61K39/395;C07K16/06;

国家 US

入库时间 2022-08-21 11:28:13

相似文献

专利

外文文献

中文文献

1. 用于小鸡的沙门氏菌感染抑制组合物和抑制小鸡沙门氏菌感染的方法 [P] . 中国专利： CN101234099A . 2008-08-06

2. 一种沙门氏菌噬菌体及在防治沙门氏菌感染的疾病的药物中的应用 [P] . 中国专利： CN111254121A . 2020-06-09

3. Salmonella Infection Inhibition Composition for Chick and Salmonella Infection Inhibition Method in Chicks [P] . BRPI0800744A2 . 2008-12-16

机译：雏鸡沙门氏菌感染抑制组合物和小鸡沙门氏菌感染抑制方法

4. Compositions and methods for diagnosing, preventing and treating Salmonella typhi and Salmonella paratyphi infection [P] . 美国专利： US10335477B2 . 2019-07-02

机译：诊断，预防和治疗伤寒沙门氏菌和副伤寒沙门氏菌感染的组合物和方法

5. COMPOSITIONS AND METHODS FOR DIAGNOSING, PREVENTING, AND TREATING SALMONELLA TYPHI AND SALMONELLA PARATYPHI INFECTION [P] . 欧洲知识产权局专利： EP2999481A4 . 2017-08-02

机译：诊断，预防和治疗沙门氏菌和沙门氏菌感染的组合物和方法

1. Adjuvant activity of Pasteurella multocida A strain, Pasteurella multocida B strain and Salmonella typhimurium bacterial DNA on cellular and humoral immunity responses against Pasteurella multocida specific strain infections in Balb/c mice [J] . Maryam Homayoon, Yahya Tahamtan, Mohammad Kargar, 亚太热带医药杂志（英文版） . 2018,第005期

2. Utility of Combining Whole Genome Sequencing with Traditional Investigational Methods To Solve Foodborne Outbreaks of Salmonella Infections Associated with Chicken: A New Tool for Tackling This Challenging Food Vehicle [J] . SAMUEL J. CROWE, ALICE GREEN, KIMBERLY HERNANDEZ, Journal of food protection . 2017,第4期

3. The age of production system and previous Salmonella infections on-farm are risk factors for low-level Salmonella infections in laying hen flocks [J] . Van Hoorebeke S., Van Immerseel F., De Vylder J., Poultry Science . 2010,第6期

4. Safety and efficacy of a salmonella gallinarum ΔcobSΔcbiA strain with potential to prevent chicken infections by salmonella gallinarum and salmonella enteritidis [J] . Paiva JB, Penha Filho RAC, Moura BS, Revista Brasileira de Ciência Avícola . 2012,第2期

5. Evaluation of cross-protection afforded by a Salmonella choleraesuis vaccine against Salmonella infections in pigs under field conditions [C] . D. Maes, K. Gibson, E. Trigd, Annual Meeting of the American Association of Swine Veterinarians . 2002

6. Live Cell Methods to Visualize Translocated Salmonella Effectors and Monitor Ca2+ Transients During Infection. [D] . Young, Alexandra Marie. 2017

7. Utility of Combining Whole Genome Sequencing with Traditional Investigational Methods To Solve Foodborne Outbreaks of Salmonella Infections Associated with Chicken: A New Tool for Tackling This Challenging Food Vehicle [O] . Samuel J. Crowe, Alice Green, Kimberly Hernandez, -1

8. Update on Extensively Drug-Resistant Salmonella Serotype Typhi Infections Among Travelers to or from Pakistan and Report of Ceftriaxone-Resistant Salmonella Serotype Typhi Infections Among Travelers to Iraq — United States, 2018–2019 [O] . Louise K. François Watkins, Alison Winstead, Grace D. Appiah, 2020

9. Detection of Salmonella C1, D and V1 Antigens, by Coagglutination, in Blood Cultures from Patients with Salmonella Infections [R] . Rockhill, R. C., Lesmana, M., Moechtar, A. M., 1980

1. BACKGROUND： Vibrio vulnifi cus inside the body could activate the NF-!B signaling pathwayand initiate the inflammatory cascade. The lung is one of the earliest organs affected by sepsisassociated with acute lung injury. High mobility group protein B1 （HMGB1） is an important late-actingpro-infl ammatory cytokine involving in the pathophysiology of sepsis. It is also involved in the injuryprocess in the lung, liver and intestine. There has been no report on the involvement of HMGB1 inVibrio vulnifi cus sepsis-induced lung injury.METHODS： Sixty rats were randomly divided into a normal control group （group A, n=10） anda Vibrio vulnificus sepsis group （group B, n=50）. Sepsis was induced in the rats by subcutaneousinjection of Vibrio vulnificus （concentration 6×108 cfu/mL, volume 0.1 mL/100g）） into the left lowerlimbs. The rats in group B were sacrifi ced separately 1, 6, 12, 24, and 48 hours after the infection.Their lungs were stored as specimens, lung water content was measured, and lung pathology wasobserved under a light microscope. The expressions of the HMGB1 gene and protein in the lungswere detected by RT-PCR and Western blot. Data were analyzed with one-way analysis of variance（ANOVA） and the LSD method for pair-wise comparison between the two groups. P〈0.05 wasconsidered statistically signifi cant.RESULTS： Compared to group A （0.652±0.177）, HMGB1 mRNA expression in the lungs ofgroup B was signifi cantly higher at 0 hour （1.161±0.358, P=0.013）, 24 hours （1.679±0.235, P=0.000）,and 48 hours （1.258±0.274, P=0.004）（P〈0.05）, and peaked at 24 hours. Compared to group A（0.594±0.190）, HMGB1 protein expression at 6 hours （1.408±0.567, P=0.026） after infection wassignificantly increased （P〈0. 05）, and peaked at 24 hours （2.415±1.064, P=0.000） after infection.Compared to group A （0.699±0.054）, lung water content was significantly increased at 6 hours（0.759±0.030, P=0.001）,12 hours （0.767±0.023, P=0.000）, 24 hours （0.771±0.043, P=0.000） and 48hours （0.789±0.137, P=0.000） after infection （P〈0.05）. Compared to group A, pathological changesat 12 hours in group B indicate marked pulmonary vascular congestion, interstitial edema andinfl ammatory infi ltration. Alveolar cavity collapse and boundaries of the alveolar septum could not beclearly identifi ed.CONCLUSION： Vibrio vulnifi cus sepsis can lead to injury in rat lungs, and increased HMGB1expression in lung tissue may be one of the mechanisms for injury from Vibrio vulnifi cus sepsis. [J] . Qiao-meng Qiu ,Zhong-wang Li ,Lu-ming Tang . 世界急诊医学杂志(英文) . 2011,第4期

2. Spectrum of Non-Typhoidal iSalmonella/iInfections among Immunocompetent Individuals [J] . Kashif Hussain ,Asif Najmuddin ,Saad Khan . 临床医学国际期刊（英文） . 2014,第20期

3. Detection of Salmonella and several common Salmonella serotypes in food by loop-mediated isothermal amplification method [J] . Zhongqiang Chen ,Ke Zhang ,Huan Yin . 食品科学与人类健康（英文） . 2015,第2期

4. Mycotoxin’s Infections and Prevention Methods: State of the Art [J] . Ishimwe Viviane ,Emmanuel Masabo ,Habiyaremye Joseph . 农业科学(英文) . 2021,第11期

5. 肠炎沙门氏菌感染对济宁百日鸡空肠形态学的影响 [C] . WANG Yuanmei ,王园美 ,LIN Lili . 中国畜牧兽医学会家禽学分会第十八次全国家禽学术讨论会 . 2017

6. 肠炎沙门氏菌实验感染鸭病理学及免疫组化与免疫荧光抗原定位方法的建立和应用研究 [A] . 颜彬 . 2008