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Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
Oligodendrocytes derived from human embryonic stem cells for remyelination and treatment of spinal cord injury
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机译:源自人类胚胎干细胞的少突胶质细胞用于髓鞘再生和治疗脊髓损伤
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摘要
This invention provides populations of neural cells bearing markers of glial cells, such as oligodendrocytes and their precursors. The populations are generated by differentiating pluripotent stem cells such as human embryonic stem cells under conditions that promote enrichment of cells with the desired phenotype or functional capability. Various combinations of differentiation factors and mitogens can be used to produce cell populations bearing markers of oligodendrocyte precursor cells. Upon further differentiation form complex processes characteristic of mature oligodendrocytes. The cells are capable of forming myelin sheaths, and can be used therapeutically improve function of the central nervous system.
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